1320s Bubonic Plague is carried by rats and flea ***** 1420s Black Death breakouts in 1429 1520s Aztec Empire destroyed by smallpox 1620s Almost all Mayflower passengers die of disease and infect much of the colony 1720s Great Pla

1320s Bubonic Plague is carried by rats and flea ***** 1420s Black Death breakouts in 1429 1520s Aztec Empire destroyed by smallpox 1620s Almost all Mayflower passengers die of disease and infect much of the colony 1720s Great Pla

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